Public Companies
Antidepressants enhance DMT efficacy in patients with severe depression: Small Pharma study
The study found that 100 per cent of patients were responsive and 92 per cent went into remission
The post Antidepressants enhance DMT efficacy in patients…
Popular antidepressants may enhance the efficacy of the classical psychedelic DMT when given to patients suffering from major depressive disorder, according to a new study by the British biotechnology company Small Pharma Inc. (TSXV: DMT) (OTCQB: DMTTF).
On Wednesday, the company announced the results from its Phase Ib study investigating the interaction between selective serotonin reuptake inhibitors (SSRIs) and SPL026, a native N, N-dimethyltryptamine (DMT). The study revealed that by the fourth week, all patients taking SSRIs responded to DMT with 92 per cent in remission from depression.
Previous studies required patients to discontinue their SSRI treatment before receiving SPL026, which often resulted in a disruptive experience for patients. This new study aimed to address this limitation and assess the safety and efficacy of co-administering SPL026 alongside SSRIs, which are the current standard of care for MDD.
Read more: Cybin inks agreement to acquire DMT drug developer Small Pharma
Read more: Small Pharma gets approval for upcoming injectable DMT trial on humans
The study involved 171 patients with moderate to severe MDD, divided into two cohorts, one with SSRIs and the other without SSRIs.
Results revealed that SPL026 was well-tolerated by all patients, with no serious drug-related adverse events reported. A small number of mild to moderate drug-related adverse events were observed, and most resolved during the dosing visit. These findings indicate the safety and tolerability of combining SPL026 with SSRIs.
The most significant and exciting outcome of the study was observed in terms of efficacy. While SPL026 demonstrated antidepressant effects in both cohorts, the SSRI Cohort exhibited a notably greater magnitude of improvement compared to the non-SSRI cohort.
The study suggests the combination potentially provides a more effective treatment option for MDD patients who have previously struggled to find relief.
Small Pharma’s approach may eliminate the need for patients to withdraw from SSRIs, thus streamlining the clinical development pathway and potentially providing earlier access to this treatment.
While these results are promising, further research and clinical trials will be necessary to validate and expand upon these findings.
Small Pharma stock fell by 5.88 per cent on Wednesday to $0.16 on the Canadian Ventures Exchange.
The post Antidepressants enhance DMT efficacy in patients with severe depression: Small Pharma study appeared first on Mugglehead Magazine.
dmt n-dimethyltryptamine dimethyltryptamine psychedelic major depressive disorder depressive disorder depression antidepressant serotonin cybin small pharma research-
Law & Regulation1 week ago
Clearmind signs agreement with Hebrew University for psychedelic compound rights
-
Psychedelics1 week ago
Cybin Announces Publication of Research Manuscript in the Journal of Medicinal Chemistry
-
Psilocybin1 week ago
California advances bill for psychedelics centers
-
Psilocybin4 days ago
Passover Perspectives: Psychedelics, Moses, and the Burning Bush
-
Psychedelics1 week ago
Psychedelics Can Offer More Than Therapy On Its Own
-
Psychedelics1 week ago
Revive Therapeutics Announces FDA Acceptance of Meeting Request for Long COVID Diagnostic Product
-
Psychedelics4 days ago
Algernon NeuroScience and the Centre for Human Drug Research to Present DMT Phase 1 Stroke Clinical Data at the Interdisciplinary Conference on Psychedelic Research June 6 – 8th, 2024
-
Psychedelics4 days ago
Revive Therapeutics Announces Type C Meeting Request Granted by FDA for Clinical Study of Bucillamine to Treat Long COVID