Cybin Inc. (NEO:CYBN | NYSE American:CYBN), a biopharmaceutical company focused on progressing Psychedelics to Therapeutics®, today announced an upcoming presentation at the Neuropsychiatric & Psychedelics Drug Development Summit taking place October 31 to November 2, 2022, in Boston, MA. The presentation, titled “CYB004-Modifications to DMT to Enhance its Therapeutic Potential,” will highlight preclinical data for CYB004, Cybin’s deuterated dimethyltryptamine (DMT) program and the advantages of deuteration on its therapeutic effect.
“I am delighted to be participating in the 5th Neuropsychiatric and Psychedelics Drug Development Summit to showcase the preclinical data that the team at Cybin have generated based on our CYB004 program. The findings from our studies that will be highlighted at the Summit demonstrate that, compared to oral DMT, CYB004 has improved bioavailability and a longer duration of action – indicating the potential to extend the therapeutic window. I look forward to engaging with thought-leaders in the field of psychedelic drug development who share our goals of developing improved treatment options for people suffering from mental health conditions.”Amy Reichelt, Ph.D., Cybin’s Director of Neuropharmacology
Title: CYB004-Modifications to DMT to Enhance its Therapeutic Potential
Date and Time: Tuesday, November 1, 2022, at 1:15 p.m. ET
CYB004 a deuterated version of N,N-dimethyltryptamine (“DMT”) that is designed to address the limitations of DMT. In preclinical studies, inhaled CYB004 demonstrated significant advantages over both IV DMT and inhaled DMT, including longer duration of action, and improved bioavailability. Based on these preclinical data, inhaled CYB004 showed a similar onset of effect and dose profile to IV DMT.
CYB004 is a new chemical entity for which a patent was issued by the U.S. Patent and Trademark Office in February 2022. The allowed claims include a range of deuterated forms of DMT and 5-MeO-DMT.
Based on preclinical results, inhaled CYB004 demonstrated:
- Improved bioavailability compared with orally administered DMT, which is known to have limited to no oral bioavailability;
- Improved bioavailability compared with inhaled DMT;
- Longer duration of effect when compared with IV DMT, indicating potential to extend therapeutic window, and rapid onset of effect.
Cybin is a leading ethical biopharmaceutical company, working with a network of world-class partners and internationally recognized scientists, on a mission to create safe and effective therapeutics for patients to address a multitude of mental health issues. Headquartered in Canada and founded in 2019, Cybin is operational in Canada, the United States, the United Kingdom, the Netherlands and Ireland. The Company is focused on progressing Psychedelics to Therapeutics by engineering proprietary drug discovery platforms, innovative drug delivery systems, novel formulation approaches and treatment regimens for mental health disorders.