Cybin to Present an Abstract and Moderate a Psychedelic Workshop at the 6th Annual Neuropsychiatric Drug Development Summit

–Abstract entitled, “Structure-activity of 2C-X psychedelics to develop a novel 5-HT_2A receptor full agonist with therapeutic potential” –

– Highlights preclinical work done to support selection of a development candidate for the Company’s phenethylamine program –

– Cybin to moderate a Psychedelic Workshop at the 6th Annual Neuropsychiatric Drug Development Summit titled “Making Psychedelic Clinical Trials a Reality: Mitigating Practical Burdens of Time, Investment & Reimbursement” on October 10, 2023 –

Cybin Inc. (NYSE American:CYBN) (NEO:CYBN) (“Cybin” or the “Company”), a clinical-stage biopharmaceutical company committed to revolutionizing mental healthcare by developing new and innovative psychedelic-based treatment options, today announced that its abstract describing a comprehensive structure-activity relationship study of a series of novel serotonergic phenethylamines has been selected for presentation at the Neuropsychiatric Drug Development Summit taking place October 11-12 in Boston, MA.

The abstract, entitled “Structure-activity of 2C-X psychedelics to develop a novel 5-HT_2A receptor full agonist with therapeutic potential,” summarizes the studies, which identified multiple potential compounds of therapeutic potential with attractive drug-like characteristics, including good safety profile, high oral bioavailability and brain penetration.

“We are extremely pleased that our abstract was selected for presentation, as this is foundational research that will inform the selection of a potential future development candidate. The Neuropsychiatric Drug Development Summit is a unique opportunity to engage with innovators in neuropsychiatry and to share ideas that ultimately drive the field forward,”

-Doug Drysdale, Chief Executive Officer of Cybin.

“There has been very little exploration of the therapeutic potential of 2C-X phenethylamines. We are therefore eager to evaluate these new compounds to gain a fuller understanding of their pharmacology, mechanisms of action, and their potential to address unmet medical needs.”

-Geoff Varty, Head of Research and Development for Cybin

Presentation Details:
Abstract Title: Structure-activity of 2C-X psychedelics to develop a novel 5-HT_2A receptor full agonist with therapeutic potential
Date and Time: Wednesday, October 11, 2023, at 5:00 p.m. ET
Authors: Alex Nivorozhkin, Geoffrey B. Varty, Clinton E. Canal, Ken Avery, Joshua A. Hartsel, Michael E. Morgan, Tina A. Mueller, Erik Stang, Michael G. Palfreyman

At the Summit, Cybin will also moderate a Psychedelic Workshop titled, “Making Psychedelic Clinical Trials a Reality: Mitigating Practical Burdens of Time, Investment & Reimbursement.” This workshop will explore key topics such as optimizing clinical trial design, addressing the need for monitoring in psychedelic trials, and the potential therapeutic advantages and durability of short-acting psychedelic compounds. The session will also highlight Cybin’s approach to developing novel second-generation psychedelic therapeutics and Cybin’s EMBARK for Clinical Trials (“EMBARK^CT”), a streamlined facilitator training program designed to support scalability for multisite, global clinical trials.

Workshop Details:
Title: Making Psychedelic Clinical Trials a Reality: Mitigating Practical Burdens of Time, Investment & Reimbursement
Date and Time: Tuesday, October 10, 2023, from 9:00 a.m. ET – 12:00 p.m. ET
Moderators (Cybin): Dr. Alex Nivorozhkin, Chief Scientific Officer of Cybin, Dr. Michael Palfreyman, Senior R&D Advisor at Cybin, and Dr. Lynn Marie Morski, President of the Psychedelic Medicine Association and a member of Cybin’s Clinical Advisory Board

For more information on the 6th Neuropsychiatric Drug Development Summit, please visit the event website here.

About Cybin

Cybin is a clinical-stage biopharmaceutical company on a mission to create safe and effective psychedelic-based therapeutics to address the large unmet need for new and innovative treatment options for people who suffer from mental health conditions.

Cybin’s goal of revolutionizing mental healthcare is supported by a network of world-class partners and internationally recognized scientists aimed at progressing proprietary drug discovery platforms, innovative drug delivery systems, and novel formulation approaches and treatment regimens. The Company is currently developing CYB003, a proprietary deuterated psilocybin analog for the treatment of major depressive disorder and CYB004, a proprietary deuterated DMT molecule for generalized anxiety disorder and has a research pipeline of investigational psychedelic-based compounds.

Headquartered in Canada and founded in 2019, Cybin is operational in Canada, the United States, the United Kingdom, the Netherlands and Ireland. For company updates and to learn more about Cybin, visit www.cybin.com or follow the team on X, LinkedIn, YouTube and Instagram.

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