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Pharma Company Working to Unlock Psychedelic Drug’s Potential for Stroke Recovery

Source: Streetwise Reports   07/09/2021

Algernon Pharmaceuticals CEO Christopher J. Moreau and Dr. David Nutt, the company’s research stroke…

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Source: Streetwise Reports   07/09/2021

Algernon Pharmaceuticals CEO Christopher J. Moreau and Dr. David Nutt, the company's research stroke consultant, discuss Algernon's upcoming Phase 1 study of DMT for stroke.

The Streetwise Live! broadcast on July 8, 2021, focused on Algernon Pharmaceuticals Inc. (AGN:CSE; AGNPF:OTCQB; AGW:FSE), the only public company currently researching psychedelics to help repair the brain post stroke. The guests, Algernon's CEO Christopher Moreau and its stroke research consultant, Dr. David Nutt, discussed the biopharma's clinical stroke program.

Host Cyndi Edwards kicked off the broadcast by asking Algernon CEO Christopher Moreau why he believes use of the psychedelic drug dimethyltryptamine (DMT) could yield positive results in stroke patients when the many drugs pursued in the past failed. Moreau cited positive DMT preclinical results.

For one, in vitro experiments, in which brain cells were exposed to DMT and various other psychedelics for different periods of time, results in increased density of complexity in the neurons. Also, an animal study showed a sub-psychedelic dose of DMT could treat depression. In a third study, a stroke insult was recreated in rats, which then were treated with DMT. After 30 days, the rats exhibited motor function recovery and a lessened area of dead cells.

"It's all about the science," Moreau added. "The data from the animals makes us hopeful."

Dr. David Nutt, who is consulting with Algernon on stroke research, added that Algernon's approach differs from that of any other company researching potential stroke drugs to date. Instead of trying to reduce damage caused by the lack of oxygen to the brain that occurs with a stroke, Algernon is looking to regrow the brain and accelerate recovery post stroke.

Like psilocybin and LSD, DMT stimulates serotonin 5-HT2A receptors in humans, which are widely distributed throughout the brain and are important for cellular and neuronal activity.

Algernon's "is a conceptually fundamentally different approach," Nutt said. It's seeing "if we can make [stroke recovery] bigger, stronger and faster through this mechanism by stimulating these HT2A receptors."

How hopeful is Nutt, on a scale of 1 to 10, about the prospect of DMT helping stroke patients, Edwards queried. He is about a 3 currently, he said, but with positive data from human trials, he hopes to move up to a 5 or 6.

"We must be realistic, but this is novel," Nutt added. "This is a different way. This is growing the brain, not just stopping the brain dying."

Edwards asked Moreau to discuss Algernon's clinical plan for DMT in stroke patients. A Phase 1 safety and dosage study is slated for October at Hammersmith Medicines Research in England, close to Nutt's location, Moreau noted. The goal for this study is to determine the ideal sub-psychedelic dose to be given and for how long.

In the Phase 2 study, which could start as early as Q1/22 if all goes as planned, Algernon will test DMT on stroke patients. First, Algernon will administer DMT to stroke patients who are in rehab, which usually begins 24 to 48 hours after the event. Next, the biopharma will target patients who are having or just had a stroke to determine how soon they can receive DMT after a stroke and if the effects will be the same as those from treatment during the rehab stage.

Were DMT approved for stroke, Edwards asked Nutt, would people's fear of psychedelics hamper uptake of the drug? Nutt responded that lots of misinformation about DMT and other psychedelics exist and that the best way to counteract that is through positive data. He added that doctors will likely be willing to use DMT given the paucity of current post stroke treatments.

In final comments, Moreau said that Algernon is a drug repurposing company, looking to repurpose DMT. Whereas the drug has not been approved, it has been used for purposes other than treating stroke patients.

"We're advancing [DMT]," he said. "We're going to do it with capital efficiency and speed. And with quality good research, hopefully that will make differences in people's lives. That's what we're trying to do."

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Streetwise Reports Disclosure:
1) Doresa Banning compiled this article for Streetwise Reports LLC and provides services to Streetwise Reports as an independent contractor. She or members of her household own securities of the following companies mentioned in the article: None. She or members of her household are paid by the following companies mentioned in this article: None.
2) The following companies mentioned in this article are billboard sponsors of Streetwise Reports: Algernon Pharmaceuticals. Click here for important disclosures about sponsor fees. As of the date of this article, an affiliate of Streetwise Reports has a consulting relationship with Algernon Pharmaceuticals. Please click here for more information.
3) Comments and opinions expressed are those of the specific experts and not of Streetwise Reports or its officers. The information provided above is for informational purposes only and is not a recommendation to buy or sell any security.
4) The article does not constitute investment advice. Each reader is encouraged to consult with his or her individual financial professional and any action a reader takes as a result of information presented here is his or her own responsibility. By opening this page, each reader accepts and agrees to Streetwise Reports' terms of use and full legal disclaimer. This article is not a solicitation for investment. Streetwise Reports does not render general or specific investment advice and the information on Streetwise Reports should not be considered a recommendation to buy or sell any security. Streetwise Reports does not endorse or recommend the business, products, services or securities of any company mentioned on Streetwise Reports.
5) From time to time, Streetwise Reports LLC and its directors, officers, employees or members of their families, as well as persons interviewed for articles and interviews on the site, may have a long or short position in securities mentioned. Directors, officers, employees or members of their immediate families are prohibited from making purchases and/or sales of those securities in the open market or otherwise from the time of the decision to publish an article until three business days after the publication of the article. The foregoing prohibition does not apply to articles that in substance only restate previously published company releases. As of the date of this article, officers and/or employees of Streetwise Reports LLC (including members of their household) own securities of Algernon Pharmaceuticals, a company mentioned in this article.
6) This article does not constitute medical advice. Officers, employees and contributors to Streetwise Reports are not licensed medical professionals. Readers should always contact their healthcare professionals for medical advice.

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Streetwise Live! Disclosures:


  1. This broadcast does not constitute investment advice. Each viewer is encouraged to consult with his or her individual financial professional and any action a viewer takes as a result of information presented here is his or her own responsibility. This broadcast is not a solicitation for investment. Streetwise Live! does not render general or specific investment advice and the information should not be considered a recommendation to buy or sell any security. Streetwise Live! does not endorse or recommend the business, products, services or securities of any company mentioned here.

  2. Statements and opinions expressed are the opinions of the presenters and not of Streetwise Live! or its officers. The presenters are wholly responsible for the validity of the statements. The presenter was not paid by Streetwise Live! for this broadcast. Streetwise Live! requires presenters to disclose any shareholdings in, or economic relationships with, companies that they write about. Streetwise Live! relies upon the authors to accurately provide this information and Streetwise Live! has no means of verifying its accuracy.

  3. The following companies discussed in this broadcast have paid a $10,000 fee to participate: Algernon Pharmaceuticals Inc.

  4. From time to time, Streetwise Live! and its directors, officers, employees or members of their families, as well as persons interviewed for broadcasts and interviews on the site, may have a long or short position in securities mentioned. As of the date of this broadcast, officers and/or employees of Streetwise Live! (including members of their household) own securities of the following companies discussed in this broadcast: Algernon Pharmaceuticals Inc. Algernon Pharmaceuticals Inc. has a consulting relationship with an affiliate of Streetwise Live! (description available at https://www.streetwisereports.com/disclaimer/html#consulting). Algernon Pharmaceuticals Inc. is a billboard sponsor of Streetwise Reports, an affiliate of Streetwise Live! (description available at https://www.streetwisereports.com/disclaimer/).

  5. Christopher Moreau - CEO owns securities of the company.

  6. Disclosures for: Dr. David Nutt - Professor, Imperial College of London. I, or members of my immediate household or family, own securities of the following companies discussed in the broadcast: None. I personally am, or members of my immediate household or family are, paid by the following companies discussed in the broadcast: Algernon Pharmaceuticals Inc. My company has a financial relationship with the following companies discussed in the broadcast: Consultant .

  7. Disclosures for: Cyndi Edwards, Host. I, or members of my immediate household or family, own securities of the following companies discussed in the broadcast: Algernon Pharmaceuticals Inc. I personally am, or members of my immediate household or family are, paid by the following companies discussed in the broadcast: None. My company has a financial relationship with the following companies discussed in the broadcast: My husband's company has a contract with Algernon to do PR but I personally do not.

( Companies Mentioned: AGN:CSE; AGNPF:OTCQB; AGW:FSE, )

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